In Bios: Genesis, one to four players start as organic compounds shortly after Earth's formation, represented by up to three Biont tokens. The Amino Acids command Metabolism, the lipids create cells, the pigments control energy absorption and storage, and the nucleic acids control templated replication. Their goal is a double origin of life: first as Autocatalytic Life (a metabolic cycle reproducing, yet not replicating, its own constituents), and the second as Darwinian Life (an Organism using a template to replicate in an RNA world). Players can play cooperative, competitive, or solitaire.
Compared to the 1st edition, there are components now for 4 instead of 3 organisms for each player.
100 new commissioned artworks.